Here are my thoughts. Good luck.
FC Barcelona +207 (Odds) over REAL MADRID CF [300/621]
"Odds" means that this wager is a push, not a loss, on a draw. It is offered at a few books. If your book only offers 3 way bets, I would still recommend a wager on Barca, but I would go down to $200 rather than $300.
Barca controlled play in the first leg and Puyol is back to shore up the defense to prevent counter attacks. Real is rumored to be sitting Zidane, and even if he plays this team has been up and down as of late so they are susceptible to the upset loss here.