Pinnacle is easily tops. Some other reduced-vig books are IIS, Hollywood, and Canbet (though Canbet has a steep curve and is thus one of the highest vig books as the money line rises). Some books also have specials -- for example -102 Tuesdays at Carib.
In terms of "best lines", books like WSEX and Intertops have more of a recreational customer base. Thus, you may find dog-friendly lines there. Books like Bowmans, Bodog, and VIP are similar, but they deal dual lines. Thus, if you show a tendency to bet dogs, they will put you on the mainstream (some would term it 'sharp') line.
In terms of selection, Olympic and 5Dimes would be my top choices as they will both have a huge number of football offerings each week.