Go see the CN tower
http://www.toronto.com/profile/147417/
(a must, great restaurant at the top, expensive, but good food) R.O.M (art gallery/museum), nhl hall of fame, walk along the waterfront (it is chilly now though), ACC, the skydome (outside) are just a few.
if you wife want to go shopping and you don't mind her spending a few $$ on the Credit card, go visit HOLT RENFREW (50 Bloor st west), she will love you for it.
Food- this place is a must if you want to spice up some romance and what a great view of the city (here is a link)
http://www.toronto.com/profile/835012/
and another
http://www.toronto.com/profile/146425/
Shopping- again there is Holt Renfrew department store, and the major downtown mall is the Eaton Centre. You both might also want to take a stroll along Queen st west (between Spadina and University ave), many great shopping stores.
Museum- ROM
http://www.toronto.com/profile/147044/
a must see....
Shows- I am guessing you are talking about theatre..
http://www.toronto.com/profile/147237/
Hotel- about a 5 minute drive from the waterfront..
right near Holt Renfrew and the shopping district, very ritzy and trendy part of town, you won't be disappointed..
http://www.marriott.com/dpp/PropertyPage.asp?MarshaCode=YYZMC
this one is closer to downtown...
http://www.toronto.dovehotels.com/crowne_plaza_toronto_centre-toronto-on.html
I hope this helps, let me know how the trip went..
or if you need anything more, feel free to ask...
Enjoy!