I watch every Clemson game so I have a pretty good read on this tem. The one advantage that Clemson has on Duke is their inside presence with Booker Grant and Sykes. Duke always struggles with Clemson's big men because they have no one to counter the points. Clemson has quick enough guards in Stitt, Rivers, and Young to create havoc on their 3 point shooters. I think the over is a really good play, and I would tend to side with the Tigers +4' in this game.
Good Luck!!