Chris Narveson (8-6, 4.49) will return from the disabled list to pitch the opener for the Brewers, his first start since lacerating his left thumb while trying to repair his glove with scissors.
The left-hander is 3-0 with a 2.84 ERA in his last three starts versus Pittsburgh.
Jeff Karstens (9-6, 3.12) will get the first chance to end the Pirates' skid against Milwaukee. He gave up three runs over 5 1/3 innings Tuesday in Pittsburgh's 5-4, 11-inning win over St. Louis, but has a 6.75 ERA over his last five starts.
Karstens is 0-4 with a 4.50 ERA in seven starts against the Brewers, giving up a startling 11 homers in his last 27 2/3 innings. Prince Fielder has taken him deep three times in 15 at-bats, while Ryan Braun has homered twice in 19.