I have not checked for sure but I think a #1 seed has won the title about 80% of the time. At Pinnacle you can arrange your wagers on all four #1 seeds and win regardless of which team wins IF one of the #1 seeds wins.
Well I know I have a shot in that I definitely make it to the finals with either Cuse or Horns. I wouldn' mind seeing Marquette beat Kansas just to get rid of the Hienrick/Collison combination.