Of course they can, but I don't like the matchup that much. As noted in another thread, Vazquez has been good of late, winning 3 of last 4, giving up just 0, 1 & 2 earned runs in the win. Yankees at home against an average to below average pitcher, and didn't hit much last night.
I'd be very careful playing the Astros big in this spot. Good luck to you, if you do. I could see a play, but certainly not a big one. Not sure why you need a big play, perhaps it's time to take a deep breath, and rethink your situation?
Again, good luck.