SaveEmailSend to
Display options
full text links
full text provider logo
actions
Cite
Favorites
share
page navigation
Title & authors
Abstract
Similar articles
Cited by
Publication types
MeSH terms
Related information
LinkOut - more resources
Review Acta Trop
. 2017 Feb;166:126-132. doi: 10.1016/j.actatropica.2016.11.028. Epub 2016 Nov 19.
Viruses of parasites as actors in the parasite-host relationship: A "m?nage ? trois"
Amaranta G?mez-Arreaza 1, Anne-Lise Haenni 2, Irene Dunia 3, Luisana Avil?n 4
Affiliations expand
PMID: 27876650 DOI: 10.1016/j.actatropica.2016.11.028
Abstract
The complex parasite-host relationship involves multiple mechanisms. Moreover, parasites infected by viruses modify this relationship adding more complexity to the system that now comprises three partners. Viruses infecting parasites were described several decades ago. However, until recently little was known about the viruses involved and their impact on the resulting disease caused to the hosts. To clarify this situation, we have concentrated on parasitic diseases caused to humans and on how virus-infected parasites could alter the symptoms inflicted on the human host. It is clear that the effect caused to the human host depends on the virus and on the parasite it has infected. Consequently, the review is divided as follows: Viruses with a possible effect on the virulence of the parasite. This section reviews pertinent articles showing that infection of parasites by viruses might increase the detrimental effect of the tandem virus-parasite on the human host (hypervirulence) or decrease virulence of the parasite (hypovirulence). Parasites as vectors affecting the transmission of viruses. In some cases, the virus-infected parasite might facilitate the transfer of the virus to the human host. Parasites harboring viruses with unidentified effects on their host. In spite of recently renewed interest in parasites in connection with their viruses, there still remains a number of cases in which the effect of the virus of a given parasite on the human host remains ambiguous. The triangular relationship between the virus, the parasite and the host, and the modulation of the pathogenicity and virulence of the parasites by viruses should be taken into account in the rationale of fighting against parasites.
Keywords: Hypervirulence; Hypovirulence; Parasite viruses; Protozoan parasites; Totiviridae; dsRNA.
Copyright ? 2016 Elsevier B.V. All rights reserved.
Similar articles
Virulence and transmissibility of pathogens: what is the relationship?
Lipsitch M, Moxon ER.
Trends Microbiol. 1997 Jan;5(1):31-7. doi: 10.1016/S0966-842X(97)81772-6.
PMID: 9025233 Review.
Analysis of a summary network of co-infection in humans reveals that parasites interact most via shared resources.
Griffiths EC, Pedersen AB, Fenton A, Petchey OL.
Proc Biol Sci. 2014 Mar 11;281(1782):20132286. doi: 10.1098/rspb.2013.2286. Print 2014 May 7.
PMID: 24619434 Free PMC article.
Fitness of parasites: pathology and selection.
Combes C.
Int J Parasitol. 1997 Jan;27(1):1-10. doi: 10.1016/s0020-7519(96)00168-3.
PMID: 9076524 Review.
How parasite interaction strategies alter virulence evolution in multi-parasite communities.
Clay PA, Rudolf VHW.
Evolution. 2019 Nov;73(11):2189-2203. doi: 10.1111/evo.13843. Epub 2019 Sep 24.
PMID: 31506940
The ecology of virulence.
Lively CM.
Ecol Lett. 2006 Oct;9(10):1089-95. doi: 10.1111/j.1461-0248.2006.00969.x.
PMID: 16972872
See all similar articles
Cited by 5 articles
Viruses of protozoan parasites and viral therapy: Is the time now right?
Barrow P, Dujardin JC, Fasel N, Greenwood AD, Osterrieder K, Lomonossoff G, Fiori PL, Atterbury R, Rossi M, Lalle M.
Virol J. 2020 Sep 29;17(1):142. doi: 10.1186/s12985-020-01410-1.
PMID: 32993724 Free PMC article. Review.
Novel RNA viruses associated with Plasmodium vivax in human malaria and Leucocytozoon parasites in avian disease.
Charon J, Grigg MJ, Eden JS, Piera KA, Rana H, William T, Rose K, Davenport MP, Anstey NM, Holmes EC.
PLoS Pathog. 2019 Dec 30;15(12):e1008216. doi: 10.1371/journal.ppat.1008216. eCollection 2019 Dec.
PMID: 31887217 Free PMC article.
Protective or Detrimental? Understanding the Role of Host Immunity in Leishmaniasis.
Dos Santos Meira C, Gedamu L.
Microorganisms. 2019 Dec 13;7(12):695. doi: 10.3390/microorganisms7120695.
PMID: 31847221 Free PMC article. Review.
Mucosal microbial parasites/symbionts in health and disease: an integrative overview.
Hirt RP.
Parasitology. 2019 Aug;146(9):1109-1115. doi: 10.1017/S0031182019000647.
PMID: 31378213 Free PMC article.
Diversity and distribution of Maize-associated totivirus strains from Tanzania.
Read DA, Featherston J, Rees DJG, Thompson GD, Roberts R, Flett BC, Mashingaidze K, Pietersen G, Kiula B, Kullaya A, Mbega ER.
Virus Genes. 2019 Jun;55(3):429-432. doi: 10.1007/s11262-019-01650-6. Epub 2019 Feb 21.
PMID: 30790190
Publication types
Review
MeSH terms
Animals
Host-Parasite Interactions*
Humans
Parasites / virology*
Parasitic Diseases / virology*
Virulence
Virus Diseases / parasitology*
Viruses*
Related information
MedGen
LinkOut - more resources
Full Text Sources
Elsevier Science
Other Literature Sources
scite Smart Citations
Medical
MedlinePlus Health Information
https://pubmed.ncbi.nlm.nih.gov/27876650/