2 vs.15
Only eight times in history has a No. 15 seed beaten a 2-seed, and three of those wins came in 2012 and 2013. In the six tournaments since, No. 2 seeds are 23-1, with the only upset being Middle Tennessee over Michigan State in 2016. Most games haven't been close, either, as 21 of those 23 wins by No. 2s came by double figures. In 2019, the Tennessee-Colgate game, which the Vols won by 7, was the closest 2/15 game since 2012.
Of the eight No. 15s to win a game, seven finished in the top two in their conference standings. The only exception was Santa Clara in 1993, which finished third in the West Coast Conference.
Among this year's 15-seeds, three of the four finished the regular season in the top two of their conference (including ties), in terms of winning percentage: Grand Canyon and Cleveland State won or shared their regular-season titles, while Iona tied for the second-best win percentage in the MAAC. The only No. 15 seed that didn't is Oral Roberts, which finished fourth in the Summit League.